HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methane → HCID 22466575, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methane | HCID 297 | — |
| Reactant | 3-Fluoroaniline | HCID 9742 | — |
| Reactant | 4-Chloro-6-nitroquinoline-3-carbonitrile | HCID 11085690 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 22466575 | HCID 22466575 | 87.5% |
Reaction Steps
Prepared from 5.00 g of 4-chloro-6-nitroquinoline-3-carbonitrile and 2.86 g of 3-fluoroaniline in the same manner as EXAMPLE 377. The crude product was dissolved in a large volume of EtOAc, treated with Darco and filtered through Celite. Solvent removal and drying in vacuo (50° C.) gave 5.77 g of 4-(3-fluorophenylamino)-6-nitroquinoline-3-carbonitrile as a yellow-orange solid: mass spectrum (electrospray, m/e): M+H 309.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06384051B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-86310800739d4152892b63d6b6a3daa2 |
| Source note | uspto-grants-2002_05 |