Methanol → HCID 178521956, compound

Participants

Reaction Steps

To 5-amino-3-cyclopropyl-N-phenyl-1H-pyrazole-l-carboxamide (0.5 g, 2 mmol) in 6 ml of methanol 0.5 ml (4.6 mmol)of phenylisocyanate and 2 ml of 10% NaOH were added. The mixture was refluxed for about 2h, then cooled, quenched with 10% HCl and extracted with ethyl acetate. The organic phase was washed with 10% HCl, water and brine. Concentration and chromatography on silica gel, eluting with 8% to 20% acetone in methylene chloride, afforded 100 mg (20% yield) of N-(3-cyclopropyl-1H-pyrazol-5-yl)-N′-phenylurea as a colorless, glassy solid.

Provenance & Evidence