HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl-3-nitro-5-cyclopropyl-1H-pyrazole-1-carboxylate → tert-butyl 3-amino-5-cyclopropyl-1H-pyrazole-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl-3-nitro-5-cyclopropyl-1H-pyrazole-1-carboxylate | HCID 11265267 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | tert-butyl 3-amino-5-cyclopropyl-1H-pyrazole-1-carboxylate | HCID 11218347 | 95% |
Reaction Steps
1.2 g (4.74 mmol) of tert-butyl-3-nitro-5-cyclopropyl-1H-pyrazole-1-carboxylate were dissolved in 20 ml of ethanol and hydrogenated in presence of 200 mg of palladium on charcoal 10% at 50 psi and room temperature to give, after filtration on celite and evaporation of the solvent, 0.96 g (95% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06387900B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-f5fa94ed91264816b207650519461718 |
| Source note | uspto-grants-2002_05 |