Water → (3RS)-1,3-dihydro-5-phenyl-3-amino-1-{2-((RS)-2-tetrahydropyranyloxy) ethyl}-2H-1,4-benzodiazepine-2-one

HRID 193536Notes

Reaction equation

HRID 193536 reaction equation
[CH:42]([Cl:43])([Cl:44])[Cl:45].[NH2:40][NH2:41].[OH2:39].[c:1]1([C:7]2=[N:8][CH:9]([N:28]3[C:29](=[O:30])[c:31]4[cH:32][cH:33][cH:34][cH:35][c:36]4[C:37]3=[O:38])[C:10](=[O:27])[N:11]([CH2:18][CH2:19][O:20][CH:21]3[O:22][CH2:23][CH2:24][CH2:25][CH2:26]3)[c:12]3[c:13]2[cH:14][cH:15][cH:16][cH:17]3)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([C:7]2=[N:8][CH:9]([NH2:28])[C:10](=[O:27])[N:11]([CH2:18][CH2:19][O:20][CH:21]3[O:22][CH2:23][CH2:24][CH2:25][CH2:26]3)[c:12]3[c:13]2[cH:14][cH:15][cH:16][cH:17]3)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

5

Reactant 4

HCID 962WaterHCID 6212ChloroformHCID 9321HydrazineHCID 14800303(3RS)-1,3-dihydro-5-phenyl-3-phthalimido-1-{2-((RS)-2-tetrahydropyranyloxy) ethyl}-2H-1,4-benzodiazepine-2-one

Product 1

HCID 14800304(3RS)-1,3-dihydro-5-phenyl-3-amino-1-{2-((RS)-2-tetrahydropyranyloxy) ethyl}-2H-1,4-benzodiazepine-2-one

Sources & evidence

ORD record
ord-298b9aaaaff14c3eaa0968dd9e4c4b03
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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