HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 19354Generated: October 26, 2026
2-Benzyloxycarbonylamino-3-bicyclo[2.2.1]hept-2-yl-acrylic acid methyl ester → 2-Amino-3-bicyclo[2.2.1]hept-2-yl-propionic acid methyl ester
https://huagongshe.com/reaction/19354
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Benzyloxycarbonylamino-3-bicyclo[2.2.1]hept-2-yl-acrylic acid methyl ester | HCID 66895573 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Amino-3-bicyclo[2.2.1]hept-2-yl-propionic acid methyl ester | HCID 14281441 | 70.1% |
Reaction Steps
In a flask was placed 2-benzyloxycarbonylamino-3-bicyclo[2.2.1]hept-2-yl-acrylic acid methyl ester (491 mg, 1.49 mmol) and methanol (15 mL). To this mixture added 10% palladium on activated carbon (60 mg) and the flask was fitted with a balloon filled with hydrogen. The mixture was allowed to stir at 25° C. for 1 h and then filtered through celite and concentrated in vacuo to afford 2-amino-3-bicyclo[2.2.1]hept-2-yl-propionic acid methyl ester (206 mg, 70%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07741327B2 |
|---|
| Source dataset | uspto-grants-2010_06 |
|---|
| ORD ID | ord-19cf7c373cac4120b495b62bacc76c44 |
|---|
| Source note | uspto-grants-2010_06 |
|---|
