1-(3-chlorophenyl)piperazin-2-one → HCID 22464361, compound

HRID 1935405Notes

Reaction equation

HRID 1935405 reaction equation
[C:1]([C:3]1[CH:16]=[CH:15][C:6]([CH2:7][N:8]2[C:12]([CH:13]=O)=[CH:11][N:10]=[CH:9]2)=[CH:5][C:4]=1[O:17][C:18]([F:21])([F:20])[F:19])#[N:2].[Cl:22][C:23]1[CH:24]=[C:25]([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][C:30]2=[O:35])[CH:26]=[CH:27][CH:28]=1>>[ClH:22].[ClH:22].[Cl:22][C:23]1[CH:24]=[C:25]([N:29]2[CH2:34][CH2:33][N:32]([CH2:13][C:12]3[N:8]([CH2:7][C:6]4[CH:15]=[CH:16][C:3]([C:1]#[N:2])=[C:4]([O:17][C:18]([F:21])([F:20])[F:19])[CH:5]=4)[CH:9]=[N:10][CH:11]=3)[CH2:31][C:30]2=[O:35])[CH:26]=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 101311141-(3-chlorophenyl)piperazin-2-oneHCID 22464389HCID 22464389, compound

Product 1

HCID 22464361HCID 22464361, compound

Procedure

The titled compound was prepared from the product of Step F (264 mg, 0.89 mmol) and the product of Step J of Example 1 using the procedure described in Step K of Example 1. Purification by silica gel column chromatography (50-65% acetoneldichloro methane) and conversion to the dihydrochloride salt using excess ethereal HCl solution gave the titled product as a white powder.

Workup

  1. customPurification by silica gel column chromatography (50-65% acetoneldichloro methane) and conversion to the dihydrochloride salt

Sources & evidence

ORD record
ord-7d2f1efa204f43cab7c07be4e78f3287
Source dataset
uspto-grants-2002_05
Patent number
US06387903B1

Reaction notes

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