Hydrochloric Acid → HCID 22464475, compound

Participants

Reaction Steps

A solution of 0.53 g (2.62 mmol) of 2-cyano-3-(2,2,2-trifluoroethoxy)pyridine and 0.66 mL (7.87 mmol) of conc. HCl in 50 mL of ethanol was hydrogenated over 0.27 g of 10% palladium on carbon at 45 psi for 1.5 h. The catalyst was removed by filtration through a pad of Celite with EtOH. The solvents were removed at reduced pressure to give the title compound: 1H NMR (CD3OD) δ8.36 (d, 1H, 5.0 Hz), 7.73 (d,1H, 8.6 Hz), 7.54 (dd, 1H, 8.4, 5.0 Hz), 4.80 (q, 2H, 8.3 Hz), 4.33 (s, 2H).

Provenance & Evidence