1,4-Dioxane hydrochloride → HCID 22464512, compound

Participants

Reaction Steps

A solution of 121 mg (0.35 mmol) 2-tert-butoxycarbonylaminomethyl-3-(2-hydroxy-2-methylpropanesulfonyl)pyridine, 10 mL 4M HCl/dioxane and 5 mL methanol was stirred at room temperature for 2 hours. The reaction was evaporated to dryness. The residue was treated with triethylamine and purified by chromatography on SiO2 using 0:100 to 5:95 methanol-chloroform yielding a yellow oil: 1H NMR (CDCl3): δ1.44 (s, 6H), 3.56 (s, 2H), 4.41 (s, 2H), 7.43 (dd, 1H), 8.32 (dd, 1H), 8.79 (dd, 1H).

Provenance & Evidence