Acetic Anhydride → HCID 54312022, compound

Participants

Reaction Steps

3.2 ml of acetic anhydride were added to 40.0 g (167 mmol) of 5 2-amino-3-carboethoxy-6-methyl-4,5,6,7-tetrahydrothieno-[2,3-c]pyridine in 250 ml of triethyl orthoformate and the mixture was boiled under nitrogen and at reflux for 3 h. After that, the mixture was evaporated right down at 80° C. on a rotary evaporator. 48.0 g (97%) of crude product were isolated as a dark oil, which is sufficiently pure for further reaction.

Provenance & Evidence