Acetic Anhydride → Ethyl n-(3-carboethoxy-6-methyl-4,5,6,7-tetrahydrothieno-[2,3-c]pyridin-2-yl)ethaneimidate

Participants

Reaction Steps

0.8 ml of acetic anhydride was added to 3.0 g (12.5 mmol) of 2-amino-3-carboethoxy-4,5,6,7-tetrahydrothieno[2,3-c]pyridine in 25 ml of triethyl orthoacetate and the mixture was boiled under nitrogen and at reflux for 2 h. After that, the mixture was evaporated right down at 80° C. on a rotary evaporator. 3.6 g (93%) of crude product were isolated as a dark oil, which is sufficiently pure for further reaction.

Provenance & Evidence