Ethanolamine → HCID 15453507, compound

Participants

Reaction Steps

17.6 ml (292 mmol) of ethanolamine were added to 86.4 g (292 mmol) of 2-ethoxymethyleneamino-3-carboethoxy-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine in 200 ml of ethanol and the mixture was boiled at reflux for 2 h. The mixture was then evaporated in vacuo and the residue was taken up in 30 ml of ethyl acetate while stirring. The solids which precipitated out overnight were filtered off with suction and rewashed with a little ethyl acetate. After recrystallizing from ethanol, 48.0 g (62%) of product having a m.p. of 163-165° C. were isolated.

Provenance & Evidence