Hydrochloric Acid → HCID 22464567, compound

Participants

Reaction Steps

14.7 g (82.7 mmol) of bis(2-chloroethyl)amine×HCl were added to 13.0 g (82.7 mmol) of 1-amino-2-methylnaphthalene in 100 ml of chlorobenzene and the mixture was boiled under nitrogen and at reflux for 90 h. The mixture was then evaporated and the residue was partitioned between methylene chloride and water at pH=9, and the organic phase was evaporated after having been dried. The crude product was purified by column chromatography (silica gel, eluent THF/methanol/ammonia, 85/13/2). 11.6 g (62%) of product were isolated.

Provenance & Evidence