HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 2-Ethoxymethyleneamino-3,5-dicarbethoxy-4,6-dihydrothieno[3,2-c]pyrrole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Diethyl 2-amino-4,6-dihydro-5H-thieno[2,3-c]pyrrole-3,5-dicarboxylate | HCID 22464559 | — |
| Solvent | Ethyl orthoformate | HCID 31214 | — |
| Product | 2-Ethoxymethyleneamino-3,5-dicarbethoxy-4,6-dihydrothieno[3,2-c]pyrrole | HCID 54410789 | 99% |
Reaction Steps
0.3 ml of acetic anhydride was added to 1.4 g (4.8 mmol) of 2-amino-3,5-dicarboethoxy-4,6-dihydrothieno[3,2-c]pyrrole in 14 ml of triethyl orthoformate, and the mixture was boiled under nitrogen and at reflux for 1 h. After that, the mixture was evaporated right down at 80° C. on a rotary evaporator. 1.6 g (99%) of crude product were isolated as a viscous oil, which is sufficiently pure for further reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06387912B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-5ee73b9fac814f02a55cc1666870ec5b |
| Source note | uspto-grants-2002_05 |