Ethanolamine → HCID 22464717, compound

HRID 1935470Notes

Reaction equation

HRID 1935470 reaction equation
[CH2:1]([CH2:3][NH2:4])[OH:2].C(O[CH:8]=[N:9][CH:10]1[C:14]([C:15]([O:17]CC)=O)=[CH:13][C:12](C)([C:20](=[O:24])[N:21]([CH3:23])[CH3:22])[S:11]1)C.[CH2:26](O)C>>[OH:2][CH2:1][CH2:3][N:4]1[C:15](=[O:17])[C:14]2[C:13]([CH3:26])=[C:12]([C:20](=[O:24])[N:21]([CH3:22])[CH3:23])[S:11][C:10]=2[N:9]=[CH:8]1

Participants

4

Reactant 3

HCID 700EthanolamineHCID 702EthanolHCID 69959475HCID 69959475, compound

Product 1

HCID 22464717HCID 22464717, compoundYield 93%

Procedure

8.0 ml (133 mmol) of ethanolamine were added to 35.6 g (114 mmol) of 2-ethoxymethyleneamino-3-carboethoxy-5-methyl-5-dimethylcarbamoylthiophene in 200 ml of ethanol, and the mixture was boiled at reflux for 2 h. The mixture was then evaporated under reduced pressure. 29.9 g (93%) of a dark viscous oil were isolated.

Workup

  1. temperatureat reflux for 2 h
  2. customThe mixture was then evaporated under reduced pressure

Sources & evidence

ORD record
ord-2bcdbc17eca442a4ae1c520626abe32d
Source dataset
uspto-grants-2002_05
Patent number
US06387912B1

Reaction notes

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