Acetic Anhydride → HCID 54376764, compound

Participants

Reaction Steps

0.5 ml of acetic anhydride was added to 3.8 g (14.9 mmol) of 2-amino-3-carboethoxy-5-ethyl-4,5,6,7-tetrahydrothieno-[3,2-c]pyridine in 40 ml of triethyl orthoformate, and the mixture was boiled under nitrogen and at reflux for 1 h. After the mixture had been decanted off from the insoluble black coating on the flask walls, it was then evaporated right down at 80° C. on a rotary evaporator. 3.5 g (94%) of crude product were isolated as a dark oil which is sufficiently pure for further reaction.

Provenance & Evidence