Ethanolamine → HCID 22464549, compound

Participants

Reaction Steps

5.0 ml (81 mmol) of ethanolamine were added to 17.0 g (55 mmol) of 2-ethoxymethyleneamino-3-carboethoxy-5-ethyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine in 130 ml of ethanol, and the mixture was boiled at reflux for 2 h. The mixture was then evaporated down to a volume of approx. 50 ml and this was thoroughly stirred in an ice bath. The fine solids which precipitated out were filtered off with suction and then washed with cold ethyl acetate. 10.5 g (63%) of a pale brown product were isolated.

Provenance & Evidence