Nitric Acid → 3-Chloro-2,4-difluoro-5-nitrobenzoic acid

HRID 1935559Notes

Reaction equation

HRID 1935559 reaction equation
[Cl:1][C:2]1[C:3]([F:12])=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([OH:7])=[O:6].[N+:13]([O-])([OH:15])=[O:14].S(=O)(=O)(O)O>>[N+:13]([C:9]1[C:10]([F:11])=[C:2]([Cl:1])[C:3]([F:12])=[C:4]([CH:8]=1)[C:5]([OH:7])=[O:6])([O-:15])=[O:14]

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 27735323-Chloro-2,4-difluorobenzoic acid

Product 1

HCID 155499183-Chloro-2,4-difluoro-5-nitrobenzoic acid

Procedure

An amount of 1 g of 3-chloro-2,4-difluorobenzoic acid is added to a mixture of 1 ml of fuming nitric acid and 1.3 ml of sulfuric acid at 0° C. The Suspension is then stirred at room temperature for 30 minutes and poured on ice. Filtration affords the desired product.

Workup

  1. additionpoured on ice
  2. filtrationFiltration

Sources & evidence

ORD record
ord-6e44759d7bbe4f5a91fe8f3918795e21
Source dataset
uspto-grants-2002_05
Patent number
US06387928B1

Reaction notes

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