2-(2,4-dichlorophenoxy)ethanethioamide → HCID 9934924, compound

HRID 1935592Notes

Reaction equation

HRID 1935592 reaction equation
[Br:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:11])[CH:8]=2)[C:3]1=[O:12].[Cl:13][C:14]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:15]=1[O:16][CH2:17][C:18]([NH2:20])=[S:19]>CC(C)=O>[BrH:1].[Cl:11][C:7]1[CH:6]=[CH:5][C:4]2[C:3]3([OH:12])[N:20]=[C:18]([CH2:17][O:16][C:15]4[CH:21]=[CH:22][C:23]([Cl:25])=[CH:24][C:14]=4[Cl:13])[S:19][CH:2]3[CH2:10][C:9]=2[CH:8]=1.[Cl:11][C:7]1[CH:6]=[CH:5][C:4]2[C:3]3([OH:12])[N:20]=[C:18]([CH2:17][O:16][C:15]4[CH:21]=[CH:22][C:23]([Cl:25])=[CH:24][C:14]=4[Cl:13])[S:19][CH:2]3[CH2:10][C:9]=2[CH:8]=1

Participants

5

Reactant 2

HCID 32625822-(2,4-dichlorophenoxy)ethanethioamideHCID 113340692-Bromo-5-chloro-2,3-dihydro-1H-inden-1-one

Product 2

HCID 9934924HCID 9934924, compoundHCID 9934925HCID 9934925, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

At room temperature, 0.25 g of 2-bromo-5-chloroindan-1-on and 0.24 g of 2-(2,4-dichlorophenoxy)-thioacetamide ware dissolved in 5 ml of dry acetone, and the mixture was stirred at room temperature for 12 h. The resulting precipitate was filtered off with suction, washed with acetone and dried under high vacuum. This yielded the hydrobromide of 6-chloro-2-(2, 4-dichlorophenoxymethyl)-8,8a-dihydroindeno[1,2-d]thiazol-3a-ol having a melting point of 170° C. (decomposition).

Workup

  1. filtrationThe resulting precipitate was filtered off with suction
  2. washwashed with acetone
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-51791b5f10f144a1873eef543f4ca907
Source dataset
uspto-grants-2002_05
Patent number
US06387935B1

Reaction notes

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