HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 6-Bromo-1,2,3,4-tetrahydro-3-quinolinamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl (6-bromo-1,2,3,4-tetrahydroquinolin-3-yl)carbamate | HCID 17758659 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-Bromo-1,2,3,4-tetrahydro-3-quinolinamine | HCID 18177089 | 220.2% |
Reaction Steps
To a solution of (6-Bromo-1,2,3,4-tetrahydro-3-quinolinyl)carbamic acid, 1,1-dimethylethyl ester (652 mg, 2 mmol) in dichloromethane at RT under argon was added trifluoroacetic acid (1 mL). After 3 hours, the mixture was concentrated. Chloroform (10 mL) was added and concentrated again in vacuo to afford the title compound (1 g), an oil, which was used without further purification. MS; M(+H)+=227.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06387926B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-22b7c889761f4e31b5c5e5a92dd0735a |
| Source note | uspto-grants-2002_05 |