Hydrochloric Acid → HCID 10936347, compound

Participants

Reaction Steps

To a solution of 1-benzyl-3-(4′-ethoxycarbonylphenyl)indazole (1 g, 2.8 mmole) dissolved in 10 mL methanol was added a sodium hydroxide solution (0.56 g in 20 mL water). After the mixture was heated under reflux for 6 hours, the methanol was removed by evaporation. The residue thus obtained was acidified with diluted HCl. After cooling in an ice bath, a solid precipitated and was collected to obtain 0.87 g 1-benzyl-3-(4′-hydroxycarbonyl-phenyl)-indazole in a yield of 94.5%.

Provenance & Evidence