Acetone → HCID 22464055, compound

Participants

Reaction Steps

A stirred mixture of the product from Step 2 (7.39 g, 0.0044 mol), acetone (130 ml), water (130 ml) and NaHCO3 (12 g, 0.143 mol) is cooled, under nitrogen in an ice bath and treated, dropwise stirring 10 min, with benzyl chloroformate (14.42 ml). It is kept in the ice bath for 20 min and at ambient temperature for 3.5 h and concentrated to remove acetone. The resulting solid is collected by filtration, washed with water, dried and recrystallized from EtOAc (Darco) to give 8.23 g of the titled product.

Provenance & Evidence