HCID 69981834, compound → HCID 69949710, compound

Participants

Reaction Steps

A mixture of the product from Step 8 (2.2 g, 0.0040 mol), 10% palladium-on-carbon catalyst (0.4 g) and ethanol (150 ml) is hydrogenated at an initial pressure of 44 p.s.i. for 2 h. The catalyst is removed by filtration through celite and the filtrate is concentrated. The residue is dissolved in CH2Cl2, filtered and concentrated to give the titled product: MS (ES) m/z 420 (M+H+), 442 (M+Na+); 1H NMR (300 MHz, CDCl3) δ0.05 (s, 6H), 0.89 (s, 9H), 2.02 (s, 3H), 2.63 (q, 1H), 3.09 (q, 1H), 3.53 (m, 3H), 3.71 (m, 2H), 4.23 (broad s, 1H), 4.71 (m, 1H), 6.14 (t, 1H), 6.58 (d, 1H), 6.98 (d, d, 1H), 7.26 (d, 1H).

Provenance & Evidence