Cycloheptanone → N-Cycloheptylglycine

HRID 1935664Notes

Reaction equation

HRID 1935664 reaction equation
[C:1]1(=O)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C[O:10][C:11](=[O:14])[CH2:12][NH2:13]>>[CH:1]1([NH:13][CH2:12][C:11]([OH:14])=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 10400CycloheptanoneHCID 69221Glycine methyl ester

Product 1

HCID 21197386N-Cycloheptylglycine

Procedure

N-Cycloheptylglycine was synthesized by reductive amination of cycloheptanone with glycine methyl ester following the procedure described in Gera et al., Immunopharmacology. 33:174-177 (1996). The crude product was converted to the N-Boc derivative (mp, 89-90° C.).

Sources & evidence

ORD record
ord-493f57ee876946379bb0360f0d2cd6ba
Source dataset
uspto-grants-2002_05
Patent number
US06388054B1

Reaction notes

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