反应详情

To a suspension of 3-(2-(2-Phenylethyl)benzimidazol-4-yl)3-oxopropionitrile (400 mg) obtained in Inventive Example 25 in ethanol (4.8 mL), while cooling in an ice bath, was added sodium borohydride (26 mg), and the mixture was stirred at the same temperature for 1 hour. The reaction solution was poured into ice water (20 mL) and extracted with ethyl acetate. The organic layer was washed with water and brine and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was crystallized from ether and collected by filtration to obtain the title compound as crystal (297 mg)

1. temperaturewhile cooling in an ice bath
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with water and brine
4. dry with materialdried over anhydrous sodium sulfate
5. customthe solvent was evaporated under a reduced pressure
6. customThe resulting residue was crystallized from ether
7. filtrationcollected by filtration