Sodium borohydride → HCID 178520876, compound

Participants

Reaction Steps

To a suspension of Ethyl 3-(6-hydroxy-2-(2-phenylethyl)benzimidazol-4-yl)-3-oxopropanoate (500 mg) obtained in Inventive Example 42 in anhydrous ethanol (10 mL), while cooling in an ice bath, was added sodium borohydride (81 mg), and the mixture was stirred at room temperature for 2 hours. The reaction solution was diluted with ice water (20 mL) and extracted with ethyl acetate. The organic layer was washed with water and brine and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. The resulting residue was crystallized from ether to obtain the desired compound as colorless crystal (424 mg).

Provenance & Evidence