Hydrogen Bromide → HCID 178515464, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-[(2,3-dihydro-6-methoxy-2-phenyl-1H-inden-1-yl)methyl]-1H-imidazole (370 mg as base) and 48 wt. % hydrobromic acid (15 ml) was heated at 130-140° C. for 2 hours with stirring. The cooled reaction mixture was poured into water and made basic (pH 8). The resulting precipitate was filtered and washed with water. The product was purified by flash chromatography (elution with a dichloromethane—methanol gradient).

Provenance & Evidence