反应详情

Polyphosphoric acid (50 g) was heated in an oil bath at 140-145° C. and 2,3-diphenyl-propanoic acid (2.5 g) was added. Heating was continued for 45 min. Water was added. The mixture was cooled and extracted with ethyl acetate. The organic extracts were washed with 1 M NaOH solution and water. After drying the solvent was evaporated under reduced pressure. The product thus obtained was further purified by trituration in heptane.

1. temperatureHeating
2. temperatureThe mixture was cooled
3. extractionextracted with ethyl acetate
4. washThe organic extracts were washed with 1 M NaOH solution and water
5. customAfter drying the solvent
6. customwas evaporated under reduced pressure
7. customThe product thus obtained
8. customwas further purified by trituration in heptane