反应详情

1-Benzyl-5-(2-phenylindan-1-ylidenemethyl)-1H-imidazole was prepared as 1-benzyl-5-(6-methoxy-2-phenylindan-1-ylidenemethyl)-1H-imidazole above except that 2-phen-ylindan-1-one was used as a starting material. In this case after evaporation of the filtrate the residue was dissolved in diluted hydrochloric acid. The product was extracted into dichloromethane. The combined organic phases were washed with water, dried over sodium sulfate and evaporated under reduced pressure. The crude product as its hydrochloride salt was used in the next step without purification.

1. customIn this case after evaporation of the filtrate the residue
2. dissolutionwas dissolved in diluted hydrochloric acid
3. extractionThe product was extracted into dichloromethane
4. washThe combined organic phases were washed with water
5. dry with materialdried over sodium sulfate
6. customevaporated under reduced pressure
7. customThe crude product as its hydrochloride salt was used in the next step without purification