反应详情

To 5-bromosalicylic acid (25 g, 115 mmol) in ethyl alcohol (300 mL) was added sulfuric acid (98%, 2 mL). The mixture was refluxed in a Dean-Stark apparatus for 2 days. The reaction mixture was cooled to room temperature. Most of the ethyl alcohol was removed by distillation. The residue was diluted with ethyl acetate, washed with water, aq. Na2CO3 and brine. The organic layer was dried (Na2SO4) and the solvent was removed to afford the title compound as a white solid.

1. temperatureThe mixture was refluxed in a Dean-Stark apparatus for 2 days
2. customMost of the ethyl alcohol was removed by distillation
3. additionThe residue was diluted with ethyl acetate
4. washwashed with water, aq. Na2CO3 and brine
5. dry with materialThe organic layer was dried (Na2SO4)
6. customthe solvent was removed