反应详情

温度

80 °C

1,3-Dichloro-2,4,6-trifluorobenzene (5.0 g, 25 mmol) and chlorosulfonic acid (10.0 ml, 150 mmol) were mixed at ambient temperature under a nitrogen atmosphere and the reaction was heated at 80° C. for 24 h. The mixture was then allowed to cool to ambient temperature and was poured onto 12 g of crushed ice. The product was extracted with diethyl ether, dried over MgSO4, and evaporated to produce 4.9 g of the title compound, which was used without fther purification. MS (EI): 300 (30, M+), 298 (28), 263 (100), 199 (80).

1. temperatureto cool to ambient temperature
2. extractionThe product was extracted with diethyl ether
3. dry with materialdried over MgSO4
4. customevaporated