5-Amino-2-methoxyphenol → HCID 15550636, compound

HRID 1936199Notes

Reaction equation

HRID 1936199 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[O:9][CH3:10])[NH2:5].[Br:11][C:12]1[C:17]([F:18])=[C:16]([F:19])[C:15]([F:20])=[C:14]([F:21])[C:13]=1[S:22](Cl)(=[O:24])=[O:23]>>[Br:11][C:12]1[C:17]([F:18])=[C:16]([F:19])[C:15]([F:20])=[C:14]([F:21])[C:13]=1[S:22]([NH:5][C:4]1[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:2]([OH:1])[CH:3]=1)(=[O:24])=[O:23]

Participants

3

Reactant 2

HCID 743145-Amino-2-methoxyphenolHCID 15550635HCID 15550635, compound

Product 1

HCID 15550636HCID 15550636, compound

Procedure

The title compound was prepared in a manner similar to that described in Example 1 by replacing p-anisidine with 3-hydroxy-4-methoxyaniline and replacing 4-fluoro-3-nitrophenylsulfonyl chloride with 2-bromo-3,4,5,6-tetrafluorophenylsulfonyl chloride (Example F). 1H-NMR (CDCl3): δ 7.28 (br s, 1H), 6.69 (m, 3H), 5.72 (s, 1H), 3.82 (s, 3H). MS (EI): 431 (20), 429 (20), 138 (100). Anal. Calcd. for C13H8BrF4NO4S: C, 36.30; H, 1.87; N, 3.26; S, 7.45. Found: C, 36.20; H, 1.90; N, 3.31; S, 7.39.

Sources & evidence

ORD record
ord-67d39736e83b4431a06d8ed471ffcf69
Source dataset
uspto-grants-2002_05
Patent number
US06388131B2

Reaction notes

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