3,4-Dimethoxyaniline → HCID 12016884, compound

HRID 1936207Notes

Reaction equation

HRID 1936207 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[NH2:6].[F:12][C:13]1[CH:14]=[C:15]([S:27](Cl)(=[O:29])=[O:28])[CH:16]=[C:17]([N+:24]([O-:26])=[O:25])[C:18]=1[O:19][C:20]([F:23])([F:22])[F:21]>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:6][S:27]([C:15]2[CH:16]=[C:17]([N+:24]([O-:26])=[O:25])[C:18]([O:19][C:20]([F:21])([F:22])[F:23])=[C:13]([F:12])[CH:14]=2)(=[O:29])=[O:28])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

4

Reactant 2

HCID 227703,4-DimethoxyanilineHCID 12016883HCID 12016883, compound

Product 1

HCID 12016884HCID 12016884, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3,4-Dimethoxyaniline (1.53 g, 10 mmol) is added to a solution of 3-fluoro-5-nitro-4-trifluoromethoxyphenylsulfonyl chloride (2.87 g, 12 mmol) in MeOH (20 ml) at ambient temperature. After stiring at room temperature for 15 min, the reaction mixture is concentrated under reduced pressure and the residue is taken up in ethyl acetate and filtered through a pad of silica gel. Concentration of the filtrate, followed by chromatography, provides the title compound.

Workup

  1. concentrationthe reaction mixture is concentrated under reduced pressure
  2. filtrationfiltered through a pad of silica gel

Sources & evidence

ORD record
ord-3d9b981d30e14afba2b3ad771c89eaa2
Source dataset
uspto-grants-2002_05
Patent number
US06388131B2

Reaction notes

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