反应详情

To a solution of 2,39 g (6,55 mmol) N-diethoxyethyl-6-(4-phenylbutoxy)hexylamine in 25 ml acetone is added 1.59 g (7.07 mmol) N-(benzyloxycarbonyloxy)succinimide. After allowing the mixture to stir for 2 hr at room temperature, acetone is removed by evaporation and 30 ml AcOEt are added thereto. The resulting mixture is washed three times with 30 ml H2O. Once separated, the AcoEt phase is dried on anhydrous Na2SO4 and evaporated to dryness, thereby yielding 3.28 g (99%) N-benzyloxycarbonyl-N-diethoxyethyl-6-(phenylbutoxy)hexylamine as an oil.

1. customacetone is removed by evaporation and 30 ml AcOEt
2. additionare added
3. washThe resulting mixture is washed three times with 30 ml H2O
4. customOnce separated
5. dry with materialthe AcoEt phase is dried on anhydrous Na2SO4
6. customevaporated to dryness