反应详情

0.9 g (1.53 mmol) N-[2-(2,2-dimethyl-4H-benzo[1,3]-dioxin-6-yl)-2-hydroxyethyl]-N-benzyloxycarbonyl-6-(4-phenylbutoxy)hexylamine is hydrogenated with 0.1 g 5% Pd/C in 30 ml MeOH at atmospheric pressure and room temperature. Once 50 ml H2 have been absorbed, the catalyst is filtered off on decalite and the filtrate concentrated to dryness to give 0.69 g (99%) N-[2-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-hydroxyethyl]-6-(4-phenylbutoxy)hexylamine.

1. customOnce 50 ml H2 have been absorbed
2. filtrationthe catalyst is filtered off on decalite
3. concentrationthe filtrate concentrated to dryness