HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromo4-(3-ethoxy-phenyl)-2-methoxy-quinoline → (5-chloro-thiophen-2-yl)-[4-(3-ethoxy-phenyl)-2-methoxy-quinolin-6-yl]-(3-methyl-3H-imidazol-4-yl)-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromo4-(3-ethoxy-phenyl)-2-methoxy-quinoline | HCID 22465419 | — |
| Reactant | (5-chloro-thiophen-2-yl)-(3-methyl-3H-imidazol-4-yl)-methanone | HCID 22465441 | — |
| Product | (5-chloro-thiophen-2-yl)-[4-(3-ethoxy-phenyl)-2-methoxy-quinolin-6-yl]-(3-methyl-3H-imidazol-4-yl)-methanol | HCID 22465418 | 72% |
Reaction Steps
Following the same procedure as that described in example 1E, 6-bromo-4-(3-ethoxy-phenyl)-2-methoxy-quinoline (800 mg, 2.23 mmol) and (5-chloro-thiophen-2-yl)-(3-methyl-3H-imidazol-4-yl)-methanone (610 mg, 2.68 mmol) generated the title compound of 23B (810 mg, 72% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06388092B2 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-fafdc16dffaa469d9d5de043cb1c5026 |
| Source note | uspto-grants-2002_05 |