HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 22465457, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (5-chloro-thiophen-2-yl)-[4-(3-methoxy-phenyl)-2-methoxy-quinolin-6-yl]-(3-methyl-3H-imidazol-4-yl)-methanol | HCID 22465430 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22465457 | HCID 22465457 | 100% |
Reaction Steps
Following the same procedure as described in example 1F (5-chloro-thiophen-2-y)-[4-(3-methoxy-phenyl)-2-methoxy-quinolin-6-yl]-(3-methyl-3H-imidazol-4-yl)-methanol (1.14 g, 2.34 mmol) was treated with HCl in aqueous THF to yield the title compound of 31B (1.12 g, 100% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06388092B2 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-3c4792356faf4b9eb5104fb6dc4ad642 |
| Source note | uspto-grants-2002_05 |