HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-[(6-Chloro-pyridin-3-yl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-isopropoxy-phenyl)-1H-quinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 86757143 | HCID 86757143 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-[(6-Chloro-pyridin-3-yl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-isopropoxy-phenyl)-1H-quinolin-2-one | HCID 22465402 | 28.5% |
Reaction Steps
Following the same procedure as described in example 1F, 6-[(6-chloro-pyridin-3-yl)-[4-(3-isopropoxy-phenyl)-2-methoxy-quinolin-6-yl]-(3-methyl-3H-imidazol-4-yl)-methanol (75 mg, 0.14 mmol) was treated with HCl in aqueous THF to yield the title compound (20 mg, 27% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06388092B2 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-edc7411ac657455aadd5cae311b1dadc |
| Source note | uspto-grants-2002_05 |