Thionyl Chloride → HCID 22465453, compound

HRID 1936315Notes

Reaction equation

HRID 1936315 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([CH:18]([C:20]4[S:21][C:22]([Cl:25])=[CH:23][CH:24]=4)O)[CH:16]=3)[N:11]([CH3:26])[C:10](=[O:27])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.S(Cl)([Cl:30])=O>C(Cl)Cl>[Cl:30][CH:18]([C:20]1[S:21][C:22]([Cl:25])=[CH:23][CH:24]=1)[C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[N:11]([CH3:26])[C:10](=[O:27])[CH:9]=[C:8]2[C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 224654214-(3-chloro-phenyl)-6-[(5-chloro-thiophen-2-yl)-hydroxy-methyl]-1-methyl-1H-quinolin-2-one

Product 1

HCID 22465453HCID 22465453, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-(3-chloro-phenyl)-6-[(5-chloro-thiophen-2-yl)-hydroxy-methyl]-1-methyl-1H-quinolin-2-one 49 mg, 0.12 mmol) in CH2Cl2 (0.5 ml) was added thionyl chloride dropwise. The reaction mixture was stirred at room temperature for four hours. Thionyl chloride was removed under reduced pressure. The crude chloride was taken up in toluene and concentrated under vacuum to give a yellow solid which was used without further purification.

Workup

  1. customThionyl chloride was removed under reduced pressure
  2. concentrationconcentrated under vacuum
  3. customto give a yellow solid which
  4. customwas used without further purification

Sources & evidence

ORD record
ord-5a815c013aeb4b69ad472135261183d3
Source dataset
uspto-grants-2002_05
Patent number
US06388092B2

Reaction notes

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