HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-[Benzo[b]thiophen-2-yl-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-(3-chloro-phenyl)-1h-quinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 22465409 | HCID 22465409 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-[Benzo[b]thiophen-2-yl-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-(3-chloro-phenyl)-1h-quinolin-2-one | HCID 22465442 | 28% |
Reaction Steps
Following the same procedure as described in example 1F, benzo[b]thiophen-2-yl-[4-(3-chloro-phenyl)-2-methoxy-quinolin-6-yl]-(3-methyl-3H-imidazol-4-yl)-methanol (147.2 mg, 0.287 mmol) was treated with HCl in aqueous THF to yield the title compound of 41B as a yellow solid (40 mg, 28% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06388092B2 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-4a44a7567aaf485dbde896a57b07ff6c |
| Source note | uspto-grants-2002_05 |