HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 2-Methyl-6-(propan-2-yl)benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | HCID 22382029 | HCID 22382029 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Methyl-6-(propan-2-yl)benzoyl chloride | HCID 22382031 | — |
Reaction Steps
A solution of 2-(1-methylethyl)-6-methylbenzoic acid (64 mg, 0.35 mmol) in dichloromethane (3 mL) containing DMF (2 drops) was treated with oxalyl chloride (0.16 mL, 1.8 mmol) and the mixture was stirred for 15 h. The mixture was concentrated, azeotroping with toluene to remove traces of oxalyl chloride and the residue was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06388084B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-ae01fd8e88f64d4b81ba91d407891daa |
| Source note | uspto-grants-2002_05 |