HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1936550Generated: November 1, 2026
Maleic Acid → 7-Chloro-3-(5-dimethylaminomethyl-[1,2,4]oxadiazol-3-yl)-5-methyl-4,5-dihydro-imidazo[1,5-a][1,4]benzodiazepin-6-one maleate
https://huagongshe.com/reaction/1936550
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Maleic Acid | HCID 444266 | — |
| Reactant | Evt-201 | HCID 9885841 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 7-Chloro-3-(5-dimethylaminomethyl-[1,2,4]oxadiazol-3-yl)-5-methyl-4,5-dihydro-imidazo[1,5-a][1,4]benzodiazepin-6-one maleate | HCID 70001919 | 94.2% |
Reaction Steps
373 mg 7-Chloro-3-(5-dimethylaminomethyl-[1,2,4]oxadiazol-3-yl)-5-methyl-4,5-dihydro-imidazo[1,5-a][1,4]benzodiazepin-6-one (I) and 116 mg maleic acid were dissloved in 3 ml hot ethanol. The salt crystalized on cooling. The suspension was stirred for 10 min at 0° C. Filtration and drying afforded 460 mg 7-Chloro-3-(5-dimethylaminomethyl-[1,2,4]oxadiazol-3-yl)-5-methyl-4,5-dihydro-imidazo[1,5-a][1,4]benzodiazepin-6-one maleate (1:1) as a whit solid. m.p. 182-184° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06391873B1 |
|---|
| Source dataset | uspto-grants-2002_05 |
|---|
| ORD ID | ord-c9165490fd954268ad07e715f0d044d3 |
|---|
| Source note | uspto-grants-2002_05 |
|---|
