Ethanol → HCID 10634531, compound

HRID 1936558Notes

Reaction equation

HRID 1936558 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:11][C:10]3=[CH:12][CH:13]=[CH:14][N:9]3[CH2:8][C:7](=[O:15])[C:6]=2[CH:16]=1.C(O)C>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:11][C:10]3=[CH:12][CH:13]=[CH:14][N:9]3[CH2:8][CH:7]([OH:15])[C:6]=2[CH:16]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 10490872HCID 10490872, compound

Product 1

HCID 10634531HCID 10634531, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The titre compound was obtained starting from 9b (112 mg, 0.45 mmol) using the procedure described above: 88% yield; melting point 118-119° C. (ethanol); IR (CHCl3) 3300 cm−1; 1H NMR (CDCl3) δ7.48 (d, 1H, J=2.1 Hz); 7.32 (d, 1H, J=8.0 Hz), 7.15 (dd, 1H, J=8.1, 2.1 Hz), 6.88 (m, 1H), 6.34 (m, 1H), 6.11 (m, 1H), 5.02 (m, 1H), 4.85 (dd, 1H, J=13.9, 1.9 Hz), 4.29 (dd, 1H, J=13.9, 6.6 Hz), 2.10 (dd, 1H, J=9.6 Hz). Anal. (C12H10CINOS): C, H, N.

Workup

  1. customThe titre compound was obtained

Sources & evidence

ORD record
ord-465630806d61493b85e5a924e60f0ec1
Source dataset
uspto-grants-2002_05
Patent number
US06391870B2

Reaction notes

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