反应详情

To a solution of 700 mg of 2,4-dimethyl-5-nitrobenzimidazole in 50 mL of methanol is added a catalytic amount of palladium-on-carbon. The resulting suspension is stirred at room temperature under hydrogen at atmospheric pressure for 15 hours. The reaction mixture is filtered on Celite with a methanol wash of the solids and the filtrate is concentrated. The residue is purified by flash column chromatography on silica gel, eluting with 5% methanol/ethyl acetate to provide 565 mg of 5-amino-2,4-dimethybenzimidazole as a tan solid.

1. filtrationThe reaction mixture is filtered on Celite with a methanol
2. washwash of the solids
3. concentrationthe filtrate is concentrated
4. customThe residue is purified by flash column chromatography on silica gel
5. washeluting with 5% methanol/ethyl acetate