反应详情

The methyl N-carbomethoxy-N,N′-dimethylthiopseudourea is combined with 8-methyl-7-nitroquinoline, as prepared in Example 7B, in 10% acetic acid in ethanol and heated to reflux. After the starting amine is consumed, the mixture is decolorized with carbon. The mixture is cooled, filtered and rotary evaporated. Upon recrystallization and drying, N,N′-dimethyl-(8-methylquinolin-7-yl)guanidine is obtained as an acetic acid salt.

1. temperatureheated to reflux
2. customAfter the starting amine is consumed
3. temperatureThe mixture is cooled
4. filtrationfiltered
5. customUpon recrystallization
6. customdrying