HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl 5-fluoro-3-benzofurancarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | 5-fluoro-1-benzofuran-3-carboxylic acid | HCID 18184308 | — |
| Product | Methyl 5-fluoro-3-benzofurancarboxylate | HCID 18184300 | — |
Reaction Steps
A solution of 5-fluorobenzofuran-3-carboxylic acid (56 g) and saturated etheral solution of hydrochloric gas (300 mL) in methanol (600 mL) was stirred for 16 h at room temperature. Further etheral HCl was added (300 mL) followed by stirring for 24 h. Concentration in vacuo gave a dark crystalline material, methyl 5-fluorobenzofuran-3-carboxylate (58 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06391882B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-5c975471851546a18be6c5a3dd7c5540 |
| Source note | uspto-grants-2002_05 |