反应详情

A stirred mixture of 7-methylthio-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine (0.60 g) and ethanolamine (0.25 ml) in ethanol (20 ml) was heated under reflux for 19 hours. More ethanolamine (0.75 ml) was added and stirring under reflux continued for 16 hours. A white crystalline solid which precipitated from the cooled reaction mixture was collected, washed with cold ethanol and recrystallized from ethanol to yield the title compound, 0.38 g, m.p. 204-205.5° C.

1. temperaturewas heated
2. temperatureunder reflux for 19 hours
3. temperatureunder reflux
4. customA white crystalline solid which precipitated from the cooled reaction mixture
5. customwas collected
6. washwashed with cold ethanol
7. customrecrystallized from ethanol