Acetic Anhydride → HCID 136029150, compound

HRID 1936658Notes

Reaction equation

HRID 1936658 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]2[N:8]=[C:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][CH2:20][CH2:21][CH3:22])[NH:10][C:11](=[O:12])[C:5]2=[CH:4][N:3]=1.[C:23](OC(=O)C)(=[O:25])[CH3:24]>>[C:23]([NH:1][C:2]1[N:7]=[C:6]2[N:8]=[C:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][CH2:20][CH2:21][CH3:22])[NH:10][C:11](=[O:12])[C:5]2=[CH:4][N:3]=1)(=[O:25])[CH3:24]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 135670763HCID 135670763, compound

Product 1

HCID 136029150HCID 136029150, compound

Procedure

A stirred mixture of 7-amino-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine (0.59 g) and acetic anhydride (5 ml) was heated under reflux for 1.5 hours. Excess acetic anhydride was removed under reduced pressure. The solid residue was washed with water and triturated with hot methanol to yield the title compound, 0.57 g, m.p. 273-4° C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 1.5 hours
  3. customExcess acetic anhydride was removed under reduced pressure
  4. washThe solid residue was washed with water
  5. customtriturated with hot methanol

Sources & evidence

ORD record
ord-c7a9dbdc4b1d4f03ae5b3ddae2abc450
Source dataset
uspto-grants-2002_05
Patent number
US06391885B1

Reaction notes

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