HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Amino-2-propanol → 7-(2-Hydroxypropylamino)-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Amino-2-propanol | HCID 4 | — |
| Reactant | 7-Methylthio-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine | HCID 135522301 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 7-(2-Hydroxypropylamino)-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine | HCID 135670770 | 83.4% |
Reaction Steps
In a similar manner to Example 38 reaction of 7-methylthio-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine (0.41 g) and 1-amino-2-propanol (0.97 g) in ethanol (15 ml) for 40 hours yielded the title compound 0.37 g, m.p. 212.5-214° C. (recrystallized from methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06391885B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-75f0314b2a8449188efa9aa68814fc86 |
| Source note | uspto-grants-2002_05 |