3-(Methylthio)propylamine → 7-(3-Methylthiopropylamino)-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine

Participants

Reaction Steps

In a similar manner to Example 38 reaction of 7-methylthio-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine (0.79 g) and methylthiopropylamine (0.50 g) in ethanol (15 ml) for 40 hours yielded a crude product which was purified by elution from silica with 40-60° petroleum ether:chloroform (gradient elution) to yield the title compound 0.52 g, m.p. 173-4° C. (recrystallized from methanol).

Provenance & Evidence