HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 7-(Carboxymethylamino)-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 136000269 | HCID 136000269 | — |
| Product | 7-(Carboxymethylamino)-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine | HCID 136023764 | 81.9% |
Reaction Steps
In a similar manner to Example 59 reaction of 7-(ethoxycarbonylmethylamino)4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine (0.54 g) and 1 Normal sodium hydroxide (5 ml) yielded the title compound 0.41 g, m.p. 252-253.5° C. (dec.) (recrystallized from ethanol:water).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06391885B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-3501dc86ece6483185aa56f6c8a99037 |
| Source note | uspto-grants-2002_05 |